Jae You
Instructor in Ophthalmology Harvard Medical School
Jae is a board-certified ophthalmologist specializing in cornea and refractive surgery. She completed fellowship training at the Wilmer Eye Institute at Johns Hopkins, following residency and internship at Brown University, and earned her medical degree from the Warren Alpert Medical School of Brown University. Certified by the American Board of Ophthalmology, she provides advanced, patient-centered eye care. Jae has experience managing ocular side effects in patients treated with antibody-drug conjugates, supporting multidisciplinary care for oncology patients. Her expertise spans corneal disease, refractive procedures, and comprehensive ophthalmology, grounded in academic medicine and evidence-based practice
Seminars
- Profiling the molecular mechanisms of ADC-induced keratopathy using a human corneal epithelial cell model, to differentiate between payload-driven apoptosis and antibody-mediated inflammation, identifying specific interventions to block each pathway
- Validating a rabbit model for ocular toxicity that correlates with clinical findings for a panel of marketed ADC, to establish a robust non-clinical platform for ranking ocular safety liabilities, enabling confident lead selection for programs with a high risk ofocular tox
- Presenting Phase I/II data on novel prophylactic strategies, such as topical IVIG or targeted corticosteroid regimens, to demonstrate how proactive management can significantly reduce the incidence and severity of ocular adverse events, improving the overall risk-benefit profile for patients
