Addressing the Unmet Need in Ocular Toxicity Through Mechanisms, Predictive Models, & Emerging Prophylactic Strategies
- Profiling the molecular mechanisms of ADC-induced keratopathy using a human corneal epithelial cell model, to differentiate between payload-driven apoptosis and antibody-mediated inflammation, identifying specific interventions to block each pathway
- Validating a rabbit model for ocular toxicity that correlates with clinical findings for a panel of marketed ADC, to establish a robust non-clinical platform for ranking ocular safety liabilities, enabling confident lead selection for programs with a high risk ofocular tox
- Presenting Phase I/II data on novel prophylactic strategies, such as topical IVIG or targeted corticosteroid regimens, to demonstrate how proactive management can significantly reduce the incidence and severity of ocular adverse events, improving the overall risk-benefit profile for patients