Implementing Rodent Models for ADC Payload Characterization to Support Discovery Screening & Inform on Pre-Clinical Species Relevance for Translation of Safety Profiles
Time: 9:30 am
day: Scientific Program Day One
Details:
- Recapitulating clinically relevant ADC toxicity in an acute rodent IV infusion model for payloads to increase efficiency / reduce costs within discovery for payload screening
- Utilizing infusion models to better understand potential species-specific sensitivities to toxicities
- Giving Merit for infusion model to inform on anticipated ADC payload PK exposures respective of SOC / comparator drugs to aid in understanding potential risk benefit for an ADC approach
