Overcoming the Limitations of In Vitro Models to Predict ADC Toxicity
Time: 8:30 am
day: Scientific Program Day Two
Details:
- Exploring why in vitro efficacy and in vivo toxicity results often fail to correlate by discussing the disconnect between cytotoxicity assays and whole-organ toxicity and identifying better biomarkers for in vitro screening
- Discussing whether 2D monocultures are sufficient for predicting ADC-induced off-target toxicity, bystander effects, and immune-related toxicities
- Understanding the role computational modelling and AI play in improving in vitro predictions – how can mathematical models integrate in vitro data to predict clinical toxicity outcomes?
