Comparing Toxicity Tolerability From Payloads in Non-Human Primates & Humans to Improve the Translatability of the ADC Candidate
Time: 9:00 am
day: Scientific Program Day One
Details:
- Comparing inhibitors in NHPs vs humans to assess toxicities in different patients
- Evaluating why there is lower tolerability in the clinic compared to NHP models while considering mediation and expression of tumour targets and payload distribution in tissues
- Investigating how we can better predict on target tumour toxicity from NHPs to humans from inhibitors by altering exposure to the payload in NHPs and humans
