Development of in vitro Assays for Off-Target ADC Hematotoxicity
Time: 1:45 pm
day: Conference Day 1
Details:
- Summarizing potential mechanisms driving off-target ADC hematotoxicity
- Developing in vitro approaches to differentiate ADCs based on toxicity to neutrophils and megakaryocytes
- Investigating mechanisms of off-target hematotoxicity including the role of FC receptor mediated uptake
