Development of in vitro Assays for Off-Target ADC Hematotoxicity

Time: 1:45 pm
day: Conference Day 1


  • Summarizing potential mechanisms driving off-target ADC hematotoxicity 
  • Developing in vitro approaches to differentiate ADCs based on toxicity to neutrophils and megakaryocytes
  • Investigating mechanisms of off-target hematotoxicity including the role of FC receptor mediated uptake