Highlighting Emerging Linker Technologies That Optimize Payload Release & Clearance to Improve Safety Profiles
Time: 12:00 pm
day: Scientific Program Day Two
Details:
- How can we engineer linkers to control payload clearance and mitigate toxicity? – Understanding how modifying linker chemistry can influence payload retention and off-target effects
- Targeting linker cleavage mechanisms for precision payload release – how tumor-specific protease linkers can help reduce systemic exposure, and why protease expression in normal tissues complicates ADC safety
- Exploring linker technologies that optimize stability, selective cleavage, and controlled clearance to create the next generation of safer ADCs
