Workshop A: Selecting an ADC Target Receptor to Reduce On-Target Off-Tumor Toxicities

Time: 9:00 am
day: Workshop Day


Discovering a way to direct more of your ADC towards the tumor and less onto the organ of toxicity and off-tumor receptor sites will allow for a huge increase of your ADC candidates’ therapeutic index. Take part in this deep dive into ADC target selection to learn how to select the correct target receptor, resulting in reduced on-target off-tumor toxicities.  

What you will gain from this session:

  • A deeper understanding of target liability assessment for ADCs to discover the optimal binding location.
  • Navigating the tumor microenvironment to release payload in the appropriate area.
  • Choosing an appropriate target receptor to bind to, in order to reduce off-target toxicities and recruit the correct enzymes to cleave the linker.
  • Understanding how to alter the binding and affinity of your antibody to not cause toxicities through disruption of critical interactions, but to still obtain your desired pharmacologic effect.